286 vetted providers offering ketamine therapy for depression, listed by city and compared against every other approach.
Esketamine (Spravato) is FDA-approved for treatment-resistant depression, and IV ketamine has years of clinical use for depression that hasn't responded to standard medication. What sets it apart is speed: many people feel a lift within hours to days rather than the weeks an antidepressant takes.
Ketamine therapy uses controlled, medically supervised doses of ketamine, given as an IV infusion, an injection, or the Spravato nasal spray, to interrupt the entrenched patterns that keep depression in place. It works on a different brain system (glutamate) than traditional antidepressants, which is why it can help when other treatments haven't.
On PsyCare+, ketamine sits in the Progressive lane of whole-person care. The clinics that do it well don't treat it as a standalone fix: they pair it with therapy and coordinate with your existing prescriber, so the rapid relief has something durable to hold onto.
Other ways to treat depression: TMS (Transcranial Magnetic Stimulation) · EMDR Therapy · Somatic & Body-Based Therapy, or see all Depression care.
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Esketamine (Spravato) is FDA-approved for treatment-resistant depression, and IV ketamine has years of clinical use for depression that hasn't responded to standard medication. What sets it apart is speed: many people feel a lift within hours to days rather than the weeks an antidepressant takes.
Many people notice a change within hours to a few days of the first sessions, which is much faster than a typical antidepressant. Clinics usually run an initial series of sessions, then space out maintenance.
Spravato is increasingly covered for treatment-resistant depression; IV ketamine is often out-of-pocket. Costs and coverage vary by clinic, so ask directly when you reach out.
It isn't right for everyone. Reputable clinics screen for blood pressure issues, certain psychiatric conditions, and substance use history before starting. A consultation is where that gets decided, not a web page.
Explore all Depression care nationwide across traditional, alternative, and progressive approaches, or browse the full PsyCare+ directory.